U-Statistics-based Tests for Multiple Genes in Genetic Association Studies

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Multiple tests for genetic effects in association studies.

1. Introduction Many common human diseases have a genetic component as measured by familial studies. Metabolic disorders such as diabetes, cardiovascular diseases such as high blood pressure, psychiatric disorders such as schizophrenia, and neurodegenerative diseases such as Alzheimer's disease all are thought to have a hereditary component. In some diseases the genetic control is through a sin...

متن کامل

Tests for Change-points Based on Recursive U-stattstics Tests for Change-points Based on Recursive U-statistics

Tests for change-points for location or regression models are often based on cumulative sums of recursive residuals. In the context of general estimable parameters (functionals of the underlying distributions), such recursive residuals may be defined in terms of recursive U-statistics. Along with some invariance principles for recursive U-statistics, asymptotic properties of some proposed tests...

متن کامل

Gene- and pathway-based association tests for multiple traits with GWAS summary statistics

To identify novel genetic variants associated with complex traits and to shed new insights on underlying biology, in addition to the most popular single SNP-single trait association analysis, it would be useful to explore multiple correlated (intermediate) traits at the gene- or pathway-level by mining existing single GWAS or meta-analyzed GWAS data. For this purpose, we present an adaptive gen...

متن کامل

Optimal Trend Tests for Genetic Association Studies of Heterogeneous Diseases

The Cochran-Armitage trend test is a standard procedure in genetic association studies. It is a directed test with high power to detect genetic effects that follow the gene-dosage model. In this paper, the author proposes optimal trend tests for genetic association studies of heterogeneous diseases. Monte-Carlo simulations show that the power gain of the optimal trend tests over the conventiona...

متن کامل

Title Robust Tests for Case-control Genetic Association Studies

May 10, 2010 Type Package Title Robust tests for case-control genetic association studies Version 1.03 Date 2010-05-10 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. The te...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Annals of Human Genetics

سال: 2008

ISSN: 0003-4800,1469-1809

DOI: 10.1111/j.1469-1809.2008.00473.x